Title

Antineuronal (anti-Ri) antibodies in a patient with steroid-responsive opsoclonus-myoclonus

Author

Dropcho EJ; Kline LB; Riser J

Address

Department of Neurology, University of Alabama, Birmingham

Source

Neurology, 43(1):207-11 1993 Jan

Abstract

A 45-year-old woman developed opsoclonus, myoclonus, and severe truncal and gait ataxia. Serum and CSF contained IgG antibodies that appear to be identical to "anti-Ri" antibodies associated with paraneoplastic opsoclonus and ataxia. The patient had a fluctuating course with exacerbations that responded well to corticosteroids and later to cyclophosphamide. Her anti-Ri antibody titer has declined significantly but still remains high. After more than 3 years of follow-up, no neoplasm has been detected.

Language

English

Unique Identifier

93140994

MESH Headings

Adrenal Cortex Hormones *TU ; Antibodies, Anti-Idiotypic *AN ANTIBODIES ANTIIDIOTYPIC ; Ataxia * ; Case Report ; Cyclophosphamide TU ; Diplopia ET ; Female ; Human ; IgG *IM ; Middle Age ; Myoclonus *DT/*IM ; Support, U.S. Gov't, Non-P.H.S. ; Syndrome

Publication Type

JOURNAL  ARTICLE

ISSN

0028-3878

Country of Publication

UNITED STATES

CAS Registry Number

0 (Adrenal Cortex Hormones); 0 (Antibodies, Anti-Idiotypic); 0 (IgG); 50-18-0 (Cyclophosphamide)