Title

Paraneoplastic opsoclonus-myoclonus associated with anti-Hu antibody [see comments]

Author

Hersh B; Dalmau J; Dangond F; Gultekin S; Geller E; Wen PY

Address

Division of Neurology, Brigham and Women's Hospital, Boston, MA 02115

Source

Neurology, 44(9):1754-5 1994 Sep

Abstract

We report a 74-year-old woman with opsoclonus, myoclonus, ataxia, and encephalopathy who had small-cell lung cancer and high titers of anti-Hu antibody in her serum. At autopsy, there were perivascular inflammatory infiltrates in the brainstem, putamen, and meninges overlying the orbital frontal cortex. Immunohistochemical studies showed the expression of the Hu antigens by the tumor and the presence of deposits of anti-Hu IgG in the patient's cortex, brainstem, and cerebellum, suggesting that anti-Hu immune response was related to the patient's clinical syndrome. This case of paraneoplastic opsoclonus, myoclonus, ataxia, and encephalopathy expands the spectrum of neurologic dysfunction associated with the anti-Hu antibody.

Language

English

Unique Identifier

95022274

MESH Headings

Aged ; Antibodies *BL ; Brain Diseases IM ; Carcinoma, Small Cell IM ; Case Report ; Cerebellar Ataxia IM ; Female ; Human ; Lung Neoplasms IM ; Myoclonus *IM ; Nerve Tissue Proteins *IM ; Ocular Motility Disorders *IM ; Paraneoplastic Syndromes *IM ; RNA-Binding Proteins *IM

Publication Type

JOURNAL  ARTICLE

ISSN

0028-3878

Country of Publication

UNITED STATES

CAS Registry Number

0 (Antibodies); 0 (Hu protein (neuronal)); 0 (Nerve Tissue Proteins); 0 (RNA-Binding Proteins)