Title

Sibling cases of opsoclonus-polymyoclonus syndrome

Author

Fujimoto Y; Isozaki E; Tanaka K; Kikuchi M; Hirai S

Address

Department of Neurology, Tokyo Metropolitan Neurological Hospital

Source

Rinsho Shinkeigaku, 37(3):261-3 1997 Mar

Abstract

We described a 34-year-old man who developed opsoclonus-polymyoclonus syndrome (OPS) associated with benign encephalitis. His older sister also suffered from the same syndrome 12 years ago. We examined HLA types in 6 patients with OPS who were admitted to our hospital, including these sibling cases. All 6 patients have type A2 antigen and statistical analysis suggested that there is a positive relationship between OPS and HLA A2 antigen. Considering the two facts that the existence of the sibling cases in this relatively rare disorder and sharing of HLA A2 antigen in our 6 cases, some genetic factors might be involved in the development of OPS.

Language

Japanese

Unique Identifier

97360405

MESH Headings

Adult ; Anti-Inflammatory Agents, Steroidal AD ANTIINFLAMMATORY AGENTS STEROIDAL ; Ataxia DT/GE ; Case Report ; Encephalitis DT/GE ; English Abstract ; Family Health ; Female ; Human ; HLA-A2 Antigen AN HLA A 02 ANTIGEN ; Male ; Myoclonus DT/*GE ; Ocular Motility Disorders DT/*GE ; Prednisolone AD ; Syndrome

Publication Type

JOURNAL  ARTICLE

ISSN

0009-918X

Country of Publication

UNITED STATES

CAS Registry Number

0 (Anti-Inflammatory Agents, Steroidal); 0 (HLA-A2 Antigen); 50-24-8 (Prednisolone)