Title

Dancing eye syndrome and hyperphosphatasemia

Author

Hasaerts DE; Gorus FK; De Meirleir LJ

Address

Department of Pediatrics, Academisch Ziekenhuis-Kinderen Vrije Universiteit Brussel, Brussels, Belgium

Source

Pediatr Neurol, 18(5):432-4 1998 May

Abstract

An 11-month-old boy with a relapsing dancing eye syndrome associated with elevation of serum alkaline phosphatase, lactate dehydrogenase, and aminotransferase activities is reported. During two clinical episodes the serum alkaline phosphatase activity increased up to four times the upper reference limit, remained elevated for a few weeks and normalized gradually in parallel with clinical improvement under steroid therapy. We found no evidence of liver or bone pathology nor of a neural crest tumor. The association between dancing eye syndrome and hyperphosphatasemia has not yet been described. The beneficial effect of the steroid therapy strengthens the hypothesis of an autoimmune origin.

Language

English

Unique Identifier

98312706

MESH Headings

Alanine Transaminase BL ; Alkaline Phosphatase *BL ; Anti-Inflammatory Agents, Steroidal TU ANTIINFLAMMATORY AGENTS STEROIDAL ; Bone and Bones EN ; Case Report ; Follow-Up Studies ; Human ; Infant ; Liver EN ; Male ; Myoclonus DT/*EN ; Ocular Motility Disorders DT/*EN ; Prednisolone TU ; Syndrome

Publication Type

JOURNAL  ARTICLE

ISSN

0887-8994

Country of Publication

UNITED STATES

CAS Registry Number

EC 2.6.1.2 (Alanine Transaminase); EC 3.1.3.1 (Alkaline Phosphatase); 0 (Anti-Inflammatory Agents, Steroidal); 50-24-8 (Prednisolone)